I-50 runs through 3 counties, 3 independent municipalities and one province: Hakurei, Sneed, Lavacast, Kebinopolis, Marjoryville, Berchill, Spawn City, Bic and Agnesium

I-50 starts from its eastern terminus in Agnesium Province and heads west in a straight but steep line for about 200m till it reaches the border with Bic County.

As one crosses the international border of the Gnomic Empire/Bicland, I-50 stays on a straight line crossing Bic Lake for another 82m till it intersects with I-59, a semi-major Interstate. For another 172m, I-50 crosses through Bictown till it reaches the border with Spawn City.

I-50 crosses another international border to be in the neutral Spawn Metro territory. One is met with scenic swamps and an old, small town. For another 100m, I-50 stays in Melungeon Isle till it reaches I-255, the Beltway of Spawn Metro. After that, I-50 goes for another 20m till it intersects with I-55, another major interstate. Then, I-50 is concurrent for only 116m till it reaches a left turn to continue onto I-50. Finally, it will stay in Spawn Metro for another 112m.

After going on another straight line in Spawn Metro, I-50 reaches Berchill, a periphery town of Spawn Metro. For 150m, I-50 goes en route till it reaches I-255 again, this time on the western edge of the Beltway. Past the Beltway is another 100m till one reaches Marjoryville.

As I-50 leaves Berchill and enters into Marjoryville, one curves around a hill and goes for about 150m till one reaches the junction with I-43, which is in the center of town. Then, it is a straight shot of 126m till one reaches another international border, but with the Macacao Empire.

I-50 finally crosses another international border, with the Macacao Empire, entering Kebinopolis. Shortly after, I-50 is at the junction of I-250, the beltway of Kebinopolis.